Preimplantation Genetic Screening procedure

Preimplantation Genetic Screening (PGS) is a method for testing the chromosomes of embryos obtained through IVF to determine if there are numerical (trisomy 21, trisomy 13, trisomy 18) or structural chromosomal anomalies and potential genetic diseases.

The process of preimplantation genetic screening includes the creation of embryos using IVF and it has the following stages:

Stage 1

The couple commences the IVF cycle with egg retrieval and fertilisation.

Stage 2

The fertilised eggs develop in the laboratory for 3 days (3rd day biopsy) or for 5 days (5th day biopsy, blastocyst stage).

Stage 3

The appropriately trained embryologist removes bioptic material from the embryos under examination using lasers that excise the cells.

Stage 4

The bioptic material is examined in specialised genetic analysis laboratories either for chromosomal anomalies or for genes associated with single-gene diseases.

Stage 5

Based on the results of the genetic analysis, only healthy embryos are transferred to the woman’s uterus, and any additional healthy embryos are frozen to be used in a subsequent cycle.